This is an oral anti-diabetic combination medication used to control high blood sugar levels in people with type 2 diabetes mellitus. It is typically prescribed when diet, exercise, and metformin alone are not enough to manage blood sugar.

Active Ingredients

• Glimepiride (3 mg): A sulfonylurea that stimulates the pancreas to release more insulin.
• Metformin (1000 mg): A biguanide that reduces glucose production in the liver and improves insulin sensitivity.

Together, they work in different ways to effectively lower blood sugar.

How It Works

1. Glimepiride:
   Boosts insulin release from the pancreas, helping lower blood sugar after meals.
2. Metformin:
   • Decreases sugar made by the liver
   • Reduces sugar absorption from food
   • Helps the body use insulin more effectively

Who Should Take It

• Adults with type 2 diabetes who are not well-controlled on metformin alone or with glimepiride alone.
• Suitable for patients requiring dual therapy for better blood sugar control.

How to Take

• Usually taken once or twice daily, with meals.
• Must be taken exactly as prescribed to avoid low blood sugar or stomach issues.

Common Side Effects

• Low blood sugar (hypoglycemia) – sweating, dizziness, hunger, confusion
• Nausea or upset stomach
• Diarrhea
• Headache
• Weight gain (due to glimepiride)

These effects are usually mild and improve over time or with dose adjustments.

Who Should Avoid It

• People with type 1 diabetes
• Patients with severe kidney or liver disease
• Those with a history of lactic acidosis
• Pregnant or breastfeeding women (unless approved by doctor)

Important Warnings

• Monitor blood sugar levels regularly.
• Avoid alcohol — it can cause lactic acidosis and worsen low blood sugar.
• Inform your doctor if you’re having any radiology exams with contrast dye.

Q1. What is Glimepiride 3 mg + Metformin 1000 mg used for?

A: This combination medicine is used to treat type 2 diabetes. It helps lower high blood sugar by boosting insulin release and improving how your body uses insulin.

Q2. How should I take this medicine?

A: Take the tablet with meals, usually once or twice a day, as prescribed. This helps avoid stomach upset and low blood sugar.

Q3. What are the common side effects?

A: Common side effects may include:

• Low blood sugar (hypoglycemia)
• Nausea or diarrhea
• Stomach discomfort
• Weight gain
• Headache or dizziness

Q4. Can I drink alcohol while using this medicine?

A: It’s best to avoid alcohol, as it increases the risk of lactic acidosis (a rare but serious condition) and can worsen low blood sugar.

Q5. What happens if I miss a dose?

A: Take the missed dose as soon as you remember. But if it’s almost time for your next dose, skip it—don’t take two doses at once.